https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 DNA damage and repair in the female germline: contributions to ART https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37385 Wed 28 Oct 2020 18:12:02 AEDT ]]> A scoping review of the information provided by fertility smartphone applications https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42962 Wed 22 Feb 2023 17:05:53 AEDT ]]> Molecular changes induced by oxidative stress that impair human sperm motility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40952 Wed 20 Jul 2022 15:22:13 AEST ]]> The role of cell cycle regulation in granulosa cells during mouse ovarian development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48058 Wed 13 Mar 2024 14:19:12 AEDT ]]> More than a simple lock and key mechanism: unraveling the intricacies of sperm-oocyte interactions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15653 Wed 11 Apr 2018 17:40:40 AEST ]]> Genome-wide analysis identifies 12 loci influencing human reproductive behavior https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29536 Wed 11 Apr 2018 15:45:41 AEST ]]> RAB-Like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15139 Wed 11 Apr 2018 14:39:08 AEST ]]> The function of molecular chaperones in human sperm-egg recognition https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21984 Wed 11 Apr 2018 14:20:20 AEST ]]> Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29296 DEAD (Asp-Glu-Ala-Asp) box protein 4 (Ddx4) gene promoter. Histopathological and functional analysis of ovaries from these mutant mice (Ctnnb1ex3cko) showed no defects in ovarian functions, oocytes, ovulation and early embryonic development. However, breeding of the Ctnnb1ex3cko female mice with males of known fertility never resulted in birth of mutant pups. Examination of uteri from time pregnant mutant females revealed defects in ectoderm differentiation leading to abnormal foetal development and premature death. Collectively, our work has established the role of active WNT/βcatenin signalling in oocyte biology and foetal development, and provides novel insights into the possible mechanisms of complications in human pregnancy such as repeated spontaneous abortion, sudden intrauterine unexpected foetal death syndrome and stillbirth.]]> Wed 11 Apr 2018 13:03:48 AEST ]]> Susceptibility of mammalian oocytes to chromosome segregation errors with maternal aging https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21949 Wed 11 Apr 2018 13:00:11 AEST ]]> Book review: The Elusive Embryo: How Women and Men Approach New Reproductive Technologies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14719 Wed 11 Apr 2018 12:33:22 AEST ]]> How does lead induce male infertility? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17518 Wed 11 Apr 2018 11:03:28 AEST ]]> Bi-allelic recessive loss-of-function variants in FANCM cause non-obstructive azoospermia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35087 G) derived from the father introduce a premature STOP codon leading to a truncated protein. FANCM exhibits enhanced testicular expression. In control subjects, immunohistochemical staining localized FANCM to the Sertoli and spermatogenic cells of seminiferous tubules with increasing intensity through germ cell development. This is consistent with its role in maintaining genomic stability in meiosis and mitosis. In the individual with SCOS carrying bi-allelic FANCM LoF variants, none or only faint expression was detected in the Sertoli cells. As further evidence, we detected two additional NOA-affected case subjects with independent FANCM homozygous nonsense variants, one from Estonia (p.Gln1701*; rs147021911) and another from Portugal (p.Arg1931*; rs144567652). The study convincingly demonstrates that bi-allelic recessive LoF variants in FANCM cause azoospermia. FANCM pathogenic variants have also been linked with doubled risk of familial breast and ovarian cancer, providing an example mechanism for the association between infertility and cancer risk, supported by published data on Fancm mutant mouse models.]]> Wed 10 Nov 2021 15:05:36 AEDT ]]> Molecular mechanisms governing fertility maintenance in thoroughbred stallions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55937 Wed 10 Jul 2024 14:54:21 AEST ]]> Negative associations of ideal family size achievement with hypertension, obesity and maternal age in women with and without polycystic ovary syndrome https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50858 Wed 09 Aug 2023 10:07:20 AEST ]]> The social determinants of mental health disorders among women with infertility: a systematic review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54615 Wed 06 Mar 2024 10:45:30 AEDT ]]> Nuclear heterogeneity is prevalent in high-quality fractionated human sperm cells typically used for assisted conception https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48760 Wed 05 Apr 2023 13:49:19 AEST ]]> Linking stress and infertility: a novel role for ghrelin https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30359 Wed 04 Sep 2019 09:47:44 AEST ]]> Not every sperm is sacred; a perspective on male infertility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47669 Tue 24 Jan 2023 15:55:08 AEDT ]]> Toll-like receptor-4 null mutation causes fetal loss and fetal growth restriction associated with impaired maternal immune tolerance in mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48564 Tue 21 Mar 2023 15:51:48 AEDT ]]> Sperm cryopreservation: current status and future developments https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50551 Tue 01 Aug 2023 10:53:37 AEST ]]> Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34014 Thu 30 May 2019 15:41:20 AEST ]]> Impact of oxidative stress on male and female germ cells: implications for fertility https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39924 Thu 30 Jun 2022 12:02:31 AEST ]]> Aphrodisiac activity of an aqueous extract of wood ear mushroom, auricularia polytricha (Heterobasidiomycetes), in male rats https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33592 Auricularia polytricha is a popular mushroom found all over the world. In this study we considered the effect of an aqueous extract of A. polytricha (AEAP) on restoring sexual performance parameters to normal, evaluated by considering observations of sexual behavior. At 0, 6, 12, 18, and 24 days, the following parameters of sexual performance were identified before and throughout the observations: mount latency, intromission latency, ejaculation latency, mounting frequency, intromission frequency, ejaculation frequency, and postejaculatory interval. Treatment of rats under stress with AEAP showed promising effects on overcoming stress-induced sexual dysfunction, on sexual performance, and on accessory sexual organs and body weight. Mounting latency, intromission latency, ejaculation latency, and postejaculatory interval parameters were significantly decreased by AEAP, whereas mounting frequency, intromission frequency, and ejaculation frequency were significantly increased by AEAP. These properties were identified in sexually dynamic and indolent male rats. We conclude that AEAP has a potent aphrodisiac activity.]]> Thu 22 Nov 2018 13:41:22 AEDT ]]> Asthma: interrelationships with pregnancy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48967 Thu 20 Apr 2023 10:09:50 AEST ]]> A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23094 Thu 14 Apr 2022 11:02:28 AEST ]]> Proteomic analysis of spermatozoa reveals caseins play a pivotal role in preventing short-term periods of subfertility in stallions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48399 Thu 11 May 2023 13:36:21 AEST ]]> Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32118 Thu 03 May 2018 12:11:55 AEST ]]> Proteomic analysis of good- and poor-quality human sperm demonstrates that several proteins are routinely aberrantly regulated https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41254 Sat 30 Jul 2022 12:54:22 AEST ]]> Biological and clinical significance of DNA damage in the male germ line https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7489 Sat 24 Mar 2018 10:46:10 AEDT ]]> Clinical, genetic, and enzymatic characterization of P450 oxidoreductase deficiency in four patients https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6962 Sat 24 Mar 2018 08:38:07 AEDT ]]> Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9572 Sat 24 Mar 2018 08:34:47 AEDT ]]> Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13898 Sat 24 Mar 2018 08:25:29 AEDT ]]> Egg donor wanted': social work with women looking for an egg donor https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17116 Sat 24 Mar 2018 08:02:29 AEDT ]]> Redox regulation of human sperm function: from the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17995 Sat 24 Mar 2018 07:56:35 AEDT ]]> The role of proteomics in understanding sperm cell biology https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5193 Sat 24 Mar 2018 07:47:44 AEDT ]]> Heat shock protein member A2 forms a stable complex with angiotensin convertingenzymeand protein disulfide isomerase A6 in human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24127 Sat 24 Mar 2018 07:16:32 AEDT ]]> Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23908 Sat 24 Mar 2018 07:10:02 AEDT ]]> Transcriptomic profiling of neonatal mouse granulosa cells reveals new insights into primordial follicle activation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46833 Mon 29 Jan 2024 18:41:10 AEDT ]]> Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36974 Fri 24 Jul 2020 14:55:41 AEST ]]> What is driving the global decline of human fertility? Need for a multidisciplinary approach to the underlying mechanisms https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55579 Fri 07 Jun 2024 11:54:16 AEST ]]> Proteomic analysis identifies tenascin-C expression is upregulated in uterine fibroids https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45565 1.5-fold) with a confidence corresponding to false discovery rate (FDR) <1% in small-, medium-, and large-sized fibroid samples regardless of MED12 mutation status. The TNC was validated on additional patient samples using Western blotting (WB) and immunohistochemistry (IHC) and confirmed significant overexpression of this protein in fibroids compared to matched ANM. Proteomic analyses have identified the increased ECM protein expression, TNC, as a hallmark of uterine fibroids regardless of MED12 mutations. Further functional studies focusing on the upregulated ECM proteins in leiomyogenesis will lead to the identification of novel ECM drug targets for fibroid treatment.]]> Fri 04 Nov 2022 14:44:56 AEDT ]]>